Efficacy and Safety of Fixed-Dose Combination of Montelukast-Desloratadine10mg/5mg in Mexican Adults with Persistent Allergic Rhinitis: a Double Blind,Randomized, Controlled and Multicenter Study

Persistent allergic rhinitis (RAP) manifests symptoms frequently and constantly. The current treatment of RAP with antihistamines and antileukotrienes is recommended as second- line treatment for the relief of the symptoms of the disease. Therefore, the objective of the present study was to compare the efficacy and safety of the combination of montelukast / desloratadine (MKDES) versus the combination of montelukast / loratadine (MKLOR) in adults with a diagnosis of RAP. The present was a multicenter, controlled, prospective, longitudinal, randomized, double-blind clinical study, with two parallel arms of active treatment (MKDES 10/5 mg vs MKLOR 10/10 mg) every 24 hours orally for 6 weeks.

Author(s):

Marco Antonio Garza-Beltrán¹, Karen Erendira Flores-Hernández¹, Victor Manuel Belalcazar², Martha
Patricia Pérez de León Vázquez3, Mario González-de-la-Parra4, Miguel A. Arreola5, Livan Delgado-
Roche5*

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